CD40L ist ein Gen, das durch das Symbol CD40LG kodiert wird. Andere Namen sind: CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5G; TNFSF5. CD40L hat eine Masse von 29.27kDa, eine Aminosäurelänge von 261, und ist an Immunodeficiency with hyper-IgM, type 1 beteiligt.
Wir bieten 19 antikörper gegen CD40L, aufgewachsen in Kaninchen, Maus, Ziege, Ratte und Hamster, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
Gewebespezifität
Specifically expressed on activated CD4+ T-lymphocytes.
Rolle bei Krankheiten
Immunodeficiency with hyper-IgM, type 1: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
Sequenzähnlichkeiten
Belongs to the tumor necrosis factor family.
Posttranslationale Modifikation
The soluble form derives from the membrane form by proteolytic processing.
Zellort
Cell membrane. Cell surface.
