CD39 ist ein Gen, das durch das Symbol ENTPD1 kodiert wird. Andere Namen sind: Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-apyrase; Lymphoid cell activation antigen; ENTPD1. CD39 hat eine Masse von 57.97kDa, eine Aminosäurelänge von 510, und ist an Spastic paraplegia 64, autosomal recessive beteiligt.
Wir bieten 27 antikörper gegen CD39, aufgewachsen in Kaninchen, Maus, Ratte und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Entrez Zusammenfassung
The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only.
Rolle bei Krankheiten
Spastic paraplegia 64, autosomal recessive: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Sequenzähnlichkeiten
Belongs to the GDA1/CD39 NTPase family.
Posttranslationale Modifikation
The N-terminus is blocked.
