CD33 ist ein Gen, das durch das Symbol CD33 kodiert wird. Andere Namen sind: Myeloid cell surface antigen Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; SIGLEC3. CD33 hat eine Masse von 39.83kDa und eine Aminosäurelänge von 364.
Wir bieten 45 antikörper gegen CD33, aufgewachsen in Kaninchen, Maus und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Primaten.
Gen- und Proteininformationen
UniProt Zusammenfassung
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).
Gewebespezifität
Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells.
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Posttranslationale Modifikation
Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition.
