CD30 ist ein Gen, das durch das Symbol TNFRSF8 kodiert wird. Andere Namen sind: Tumor necrosis factor receptor superfamily member 8L receptor; Ki-1 antigen; Lymphocyte activation antigen TNFRSF8; D1S166E. CD30 hat eine Masse von 63.75kDa und eine Aminosäurelänge von 595.
Wir bieten 48 antikörper gegen CD30, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and ChIP mit Proben abgeleitet von Human und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).
Entrez Zusammenfassung
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Gewebespezifität
Detected in alveolar macrophages (at protein level).
Sequenzähnlichkeiten
Belongs to the TNFR8 family.
Posttranslationale Modifikation
Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832).
