CD27 ist ein Gen, das durch das Symbol CD27 kodiert wird. Andere Namen sind: CD27 antigenL receptor; T-cell activation antigen T14; Tumor necrosis factor receptor superfamily member 7; TNFRSF7. CD27 hat eine Masse von 29.14kDa, eine Aminosäurelänge von 260, und ist an Lymphoproliferative syndrome 2 beteiligt.
Wir bieten 58 antikörper gegen CD27, aufgewachsen in Kaninchen, Maus, Ziege, Hamster und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Schwein.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Gewebespezifität
Found in most T-lymphocytes.
Rolle bei Krankheiten
Lymphoproliferative syndrome 2: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
Posttranslationale Modifikation
Phosphorylated.
