CD1b ist ein Gen, das durch das Symbol CD1B kodiert wird. Es ist auch bekannt als T-cell surface glycoprotein CD1B. CD1b hat eine Masse von 36.94kDa und eine Aminosäurelänge von 333.
Wir bieten 13 antikörper gegen CD1b, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Entrez Zusammenfassung
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.
Gewebespezifität
Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Zellort
Cell membrane. Endosome membrane. Lysosome membrane.
Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.
