CD16 ist ein Gen, das durch das Symbol FCGR3A kodiert wird. Andere Namen sind: Low affinity immunoglobulin gamma Fc region receptor III-Aa antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; FcR-10; IgG Fc receptor III-2; FCGR3AA; FCG3; FCGR3; IGFR3. CD16 hat eine Masse von 29.09kDa, eine Aminosäurelänge von 254, und ist an Immunodeficiency 20 beteiligt.
Wir bieten 51 antikörper gegen CD16, aufgewachsen in Kaninchen, Maus und Ratte, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein, Schaf, Katze und Primaten.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Entrez Zusammenfassung
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.
Rolle bei Krankheiten
Immunodeficiency 20: A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV).
Posttranslationale Modifikation
Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
Zellort
Cell membrane. Secreted.
Exists also as a soluble receptor.
