CD153 ist ein Gen, das durch das Symbol TNFSF8 kodiert wird. Andere Namen sind: Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; TNFSF8; CD30L; CD30LG. CD153 hat eine Masse von 26.02kDa und eine Aminosäurelänge von 234.
Wir bieten 7 antikörper gegen CD153, aufgewachsen in Kaninchen, welche geeignet sind für WB, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
Entrez Zusammenfassung
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Sequenzähnlichkeiten
Belongs to the tumor necrosis factor family.
