CD11c ist ein Gen, das durch das Symbol ITGAX kodiert wird. Andere Namen sind: Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; ITGAX. CD11c hat eine Masse von 127.83kDa und eine Aminosäurelänge von 1163.
Wir bieten 33 antikörper gegen CD11c, aufgewachsen in Kaninchen, Maus und Hamster, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Affe, Schaf, Hund, Goat und Raccoon.
Gen- und Proteininformationen
UniProt Zusammenfassung
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Entrez Zusammenfassung
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Predominantly expressed in monocytes and granulocytes.
Sequenzähnlichkeiten
Belongs to the integrin alpha chain family.
