CCR7 ist ein Gen, das durch das Symbol CCR7 kodiert wird. Andere Namen sind: C-C chemokine receptor type 7; C-C CKR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; MIP-3 beta receptor; CMKBR7; EVI1. CCR7 hat eine Masse von 42.87kDa und eine Aminosäurelänge von 378.
Wir bieten 18 antikörper gegen CCR7, aufgewachsen in Kaninchen, Ziege, Ratte und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC, IP and Dot mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
Gewebespezifität
Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
