Caspase-12 ist ein Gen, das durch das Symbol CASP12 kodiert wird. Andere Namen sind: Inactive CASP-12; CASP12. Caspase-12 hat eine Masse von 38.91kDa und eine Aminosäurelänge von 341.
Wir bieten 7 antikörper gegen Caspase-12, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Entrez Zusammenfassung
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
Gewebespezifität
Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.
Sequenzähnlichkeiten
Belongs to the peptidase C14A family.
