Cardiac Troponin T ist ein Gen, das durch das Symbol TNNT2 kodiert wird. Andere Namen sind: Troponin T, cardiac muscle; TnTc; Cardiac muscle troponin T; cTnT; TNNT2. Cardiac Troponin T hat eine Masse von 35.92kDa, eine Aminosäurelänge von 298, und ist an folgenden Krankheiten beteiligt: Cardiomyopathy, familial hypertrophic 2; Cardiomyopathy, dilated 1D; Cardiomyopathy, familial restrictive 3.
Wir bieten 9 antikörper gegen Cardiac Troponin T, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and ChIP mit Proben abgeleitet von Human, Maus, Ratte, Rind und Schwein.
Gen- und Proteininformationen
UniProt Zusammenfassung
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Entrez Zusammenfassung
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.
Gewebespezifität
Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.
Rolle bei Krankheiten
Cardiomyopathy, familial hypertrophic 2: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Cardiomyopathy, dilated 1D: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial restrictive 3: A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
Sequenzähnlichkeiten
Belongs to the troponin T family.
Posttranslationale Modifikation
Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.
