CAMKK2 ist ein Gen, das durch das Symbol CAMKK2 kodiert wird. Andere Namen sind: Calcium/calmodulin-dependent protein kinase kinase 2; CaM-KK 2; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CAMKKB; KIAA0787. CAMKK2 hat eine Masse von 64.75kDa und eine Aminosäurelänge von 588.
Wir bieten 6 antikörper gegen CAMKK2, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Entrez Zusammenfassung
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.
Gewebespezifität
Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Posttranslationale Modifikation
Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
Zellort
Nucleus. Cytoplasm. Cell projection > Neuron projection.
Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction.
