Calumenin ist ein Gen, das durch das Symbol CALU kodiert wird. Andere Namen sind: Crocalbin; IEF SSP 9302; CALU. Calumenin hat eine Masse von 37.11kDa und eine Aminosäurelänge von 315.
Wir bieten 6 antikörper gegen Calumenin, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).
Entrez Zusammenfassung
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gewebespezifität
Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.
Sequenzähnlichkeiten
Belongs to the CREC family.
Zellort
Endoplasmic reticulum membrane. Golgi apparatus. Secreted. Melanosome. Sarcoplasmic reticulum lumen.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
