Calpastatin ist ein Gen, das durch das Symbol CAST kodiert wird. Andere Namen sind: Calpain inhibitor; Sperm BS-17 component; CAST. Calpastatin hat eine Masse von 76.57kDa, eine Aminosäurelänge von 708, und ist an Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads beteiligt.
Wir bieten 6 antikörper gegen Calpastatin, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Entrez Zusammenfassung
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
Rolle bei Krankheiten
Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads: An autosomal recessive disease characterized by generalized, continuous shedding of the outer layers of the epidermis, leukonychia, acral punctate keratosis, cheilitis, knuckle pads with multiple hyperkeratotic micropapules involving the interphalangeal joints, and palmoplantar keratoderma.
Sequenzähnlichkeiten
Belongs to the protease inhibitor I27 (calpastatin) family.
Posttranslationale Modifikation
The N-terminus is blocked.
