Calcipressin 1 ist ein Gen, das durch das Symbol RCAN1 kodiert wird. Andere Namen sind: Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1; RCAN1; ADAPT78; CSP1; DSC1; DSCR1. Calcipressin 1 hat eine Masse von 28.08kDa und eine Aminosäurelänge von 252.
Wir bieten 7 antikörper gegen Calcipressin 1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
Sequenzähnlichkeiten
Belongs to the RCAN family.
Posttranslationale Modifikation
Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.
