Bub3 ist ein Gen, das durch das Symbol BUB3 kodiert wird. Es ist auch bekannt als Mitotic checkpoint protein BUB3. Bub3 hat eine Masse von 37.16kDa und eine Aminosäurelänge von 328.
Wir bieten 10 antikörper gegen Bub3, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Entrez Zusammenfassung
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Sequenzähnlichkeiten
Belongs to the WD repeat BUB3 family.
Posttranslationale Modifikation
Poly-ADP-ribosylated by PARP1.
Zellort
Nucleus. Chromosome > Centromere > Kinetochore.
Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition.
