BTF ist ein Gen, das durch das Symbol BCLAF1 kodiert wird. Andere Namen sind: Bcl-2-associated transcription factor 1; BCLAF1 and THRAP3 family member 1; BCLAF1; KIAA0164. BTF hat eine Masse von 106.12kDa und eine Aminosäurelänge von 920.
Wir bieten 7 antikörper gegen BTF, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Entrez Zusammenfassung
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Ubiquitous.
Sequenzähnlichkeiten
Belongs to the BCLAF1/THRAP3 family.
Posttranslationale Modifikation
Citrullinated by PADI4.
Zellort
Cytoplasm. Nucleus. Nucleus speckle. Nucleus > Nucleoplasm.
