BS69 ist ein Gen, das durch das Symbol ZMYND11 kodiert wird. Andere Namen sind: Zinc finger MYND domain-containing protein 11; Adenovirus 5 E1A-binding protein; Bone morphogenetic protein receptor-associated molecule 1; Protein ZMYND11; BRAM1. BS69 hat eine Masse von 70.96kDa, eine Aminosäurelänge von 602, und ist an Mental retardation, autosomal dominant 30 beteiligt.
Wir bieten 6 antikörper gegen BS69, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
Entrez Zusammenfassung
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gewebespezifität
Ubiquitous.
Rolle bei Krankheiten
Mental retardation, autosomal dominant 30: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD30 patients manifest mild intellectual disability and subtle facial dysmorphisms, including hypertelorism, ptosis, and a wide mouth.
Posttranslationale Modifikation
Sumoylated following its interaction with PIAS1 and UBE2I.
Zellort
Nucleus. Chromosome.
Associates with chromatin and mitotic chromosomes.
