Bone Sialoprotein ist ein Gen, das durch das Symbol IBSP kodiert wird. Andere Namen sind: Bone sialoprotein 2 II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein; IBSP; BNSP. Bone Sialoprotein hat eine Masse von 35.15kDa und eine Aminosäurelänge von 317.
Wir bieten 11 antikörper gegen Bone Sialoprotein, aufgewachsen in Kaninchen, Maus, Ziege und Huhn, welche geeignet sind für WB, IHC, ELISA, ICC/IF and RIA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
Entrez Zusammenfassung
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
Posttranslationale Modifikation
N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains.
