BMP15 ist ein Gen, das durch das Symbol BMP15 kodiert wird. Andere Namen sind: Bone morphogenetic protein 15; BMP-15; Growth/differentiation factor 9B; GDF-9B; GDF9B. BMP15 hat eine Masse von 45.06kDa, eine Aminosäurelänge von 392, und ist an folgenden Krankheiten beteiligt: Ovarian dysgenesis 2; Premature ovarian failure 4.
Wir bieten 6 antikörper gegen BMP15, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Entrez Zusammenfassung
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure.
Rolle bei Krankheiten
Ovarian dysgenesis 2: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
Premature ovarian failure 4: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Sequenzähnlichkeiten
Belongs to the TGF-beta family.
