Blood Group H2 antigen ist ein Gen, das durch das Symbol ABO kodiert wird. Andere Namen sind: Histo-blood group ABO system transferase; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Histo-blood group A transferase; A transferase; Histo-blood group B transferase; B transferase; NAGAT; ABO. Blood Group H2 antigen hat eine Masse von 40.93kDa und eine Aminosäurelänge von 354.
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Gen- und Proteininformationen
UniProt Zusammenfassung
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
Entrez Zusammenfassung
This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene.
Sequenzähnlichkeiten
Belongs to the glycosyltransferase 6 family.
Posttranslationale Modifikation
The soluble form derives from the membrane form by proteolytic processing.
Zellort
Golgi apparatus > Golgi stack membrane. Secreted.
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
