Bik ist ein Gen, das durch das Symbol BIK kodiert wird. Andere Namen sind: Bcl-2-interacting killer; Apoptosis inducer NBK; BIP1; BP4; NBK. Bik hat eine Masse von 18.02kDa und eine Aminosäurelänge von 160.
Wir bieten 9 antikörper gegen Bik, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Entrez Zusammenfassung
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.
Posttranslationale Modifikation
Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.
Zellort
Endomembrane system. Mitochondrion membrane.
Around the nuclear envelope, and in cytoplasmic membranes.
