BCMA ist ein Gen, das durch das Symbol TNFRSF17 kodiert wird. Andere Namen sind: Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; TNFRSF17; BCM. BCMA hat eine Masse von 20.17kDa und eine Aminosäurelänge von 184.
Wir bieten 34 antikörper gegen BCMA, aufgewachsen in Kaninchen, Maus und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Gewebespezifität
Expressed in mature B-cells, but not in T-cells or monocytes.
Zellort
Cell membrane. Endomembrane system.
Perinuclear Golgi-like structures.
