Bcl2L2 ist ein Gen, das durch das Symbol BCL2L2 kodiert wird. Andere Namen sind: Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W; BCLW; KIAA0271. Bcl2L2 hat eine Masse von 20.75kDa und eine Aminosäurelänge von 193.
Wir bieten 10 antikörper gegen Bcl2L2, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Entrez Zusammenfassung
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
Gewebespezifität
Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
Sequenzähnlichkeiten
Belongs to the Bcl-2 family.
Zellort
Mitochondrion membrane.
Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
