Bak ist ein Gen, das durch das Symbol BAK1 kodiert wird. Andere Namen sind: Bcl-2 homologous antagonist/killer; Apoptosis regulator Bcl-2-like protein 7; Bcl2-L-71; BCL2L7; CDN1. Bak hat eine Masse von 23.41kDa und eine Aminosäurelänge von 211.
Wir bieten 12 antikörper gegen Bak, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
Entrez Zusammenfassung
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Gewebespezifität
Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Sequenzähnlichkeiten
Belongs to the Bcl-2 family.
Zellort
Mitochondrion outer membrane.
