Axin 2 ist ein Gen, das durch das Symbol AXIN2 kodiert wird. Andere Namen sind: Axin-2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin; AXIN2. Axin 2 hat eine Masse von 93.56kDa, eine Aminosäurelänge von 843, und ist an folgenden Krankheiten beteiligt: Colorectal cancer; Oligodontia-colorectal cancer syndrome.
Wir bieten 12 antikörper gegen Axin 2, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Entrez Zusammenfassung
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Gewebespezifität
Expressed in brain and lymphoblast.
Rolle bei Krankheiten
Colorectal cancer: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Oligodontia-colorectal cancer syndrome: Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
Posttranslationale Modifikation
Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
