ASF1A ist ein Gen, das durch das Symbol ASF1A kodiert wird. Andere Namen sind: Histone chaperone Anti-silencing function protein 1 homolog A; hAsf1; CCG1-interacting factor A; CIA. ASF1A hat eine Masse von 22.97kDa und eine Aminosäurelänge von 204.
Wir bieten 11 antikörper gegen ASF1A, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and Dot mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Entrez Zusammenfassung
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.
Gewebespezifität
Ubiquitously expressed.
Sequenzähnlichkeiten
Belongs to the ASF1 family.
Posttranslationale Modifikation
Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation.
