Apolipoprotein L 1 ist ein Gen, das durch das Symbol APOL1 kodiert wird. Andere Namen sind: Apolipoprotein L1; Apolipoprotein L; Apo-L; Apolipoprotein L-I; ApoL-I; APOL1; APOL. Apolipoprotein L 1 hat eine Masse von 43.97kDa, eine Aminosäurelänge von 398, und ist an Focal segmental glomerulosclerosis 4 beteiligt.
Wir bieten 7 antikörper gegen Apolipoprotein L 1, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
Entrez Zusammenfassung
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.
Rolle bei Krankheiten
Focal segmental glomerulosclerosis 4: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Sequenzähnlichkeiten
Belongs to the apolipoprotein L family.
Posttranslationale Modifikation
Phosphorylated by FAM20C in the extracellular medium.
