APLP1 ist ein Gen, das durch das Symbol APLP1 kodiert wird. Andere Namen sind: Amyloid-like protein 1; APLP. APLP1 hat eine Masse von 72.18kDa und eine Aminosäurelänge von 650.
Wir bieten 6 antikörper gegen APLP1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Entrez Zusammenfassung
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Gewebespezifität
Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
Sequenzähnlichkeiten
Belongs to the APP family.
Posttranslationale Modifikation
Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).
