Apg7 ist ein Gen, das durch das Symbol ATG7 kodiert wird. Andere Namen sind: Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7-like; Ubiquitin-activating enzyme E1-like protein; ATG7L. Apg7 hat eine Masse von 77.96kDa und eine Aminosäurelänge von 703.
Wir bieten 9 antikörper gegen Apg7, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).
Entrez Zusammenfassung
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
Sequenzähnlichkeiten
Belongs to the ATG7 family.
Posttranslationale Modifikation
Acetylated by EP300.
Zellort
Cytoplasm. Preautophagosomal structure.
Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
