Apg12 ist ein Gen, das durch das Symbol ATG12 kodiert wird. Andere Namen sind: Ubiquitin-like protein ATG12; Autophagy-related protein 12-like; ATG12L. Apg12 hat eine Masse von 15.11kDa und eine Aminosäurelänge von 140.
Wir bieten 11 antikörper gegen Apg12, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte, Affe und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.
Entrez Zusammenfassung
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998
Gewebespezifität
Ubiquitous.
Sequenzähnlichkeiten
Belongs to the ATG12 family.
Posttranslationale Modifikation
Acetylated by EP300.
Zellort
Cytoplasm. Preautophagosomal structure membrane.
TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
