ANKRD1 ist ein Gen, das durch das Symbol ANKRD1 kodiert wird. Andere Namen sind: Ankyrin repeat domain-containing protein 1; Cardiac ankyrin repeat protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein; C193; CARP; HA1A2. ANKRD1 hat eine Masse von 36.25kDa, eine Aminosäurelänge von 319, und ist an Total anomalous pulmonary venous return beteiligt.
Wir bieten 8 antikörper gegen ANKRD1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
Entrez Zusammenfassung
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.
Gewebespezifität
Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
Rolle bei Krankheiten
Total anomalous pulmonary venous return: Rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.
