AMHR2 ist ein Gen, das durch das Symbol AMHR2 kodiert wird. Andere Namen sind: Anti-Muellerian hormone type-2 receptor; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; AMHR; MISR2. AMHR2 hat eine Masse von 62.75kDa, eine Aminosäurelänge von 573, und ist an Persistent Muellerian duct syndrome 2 beteiligt.
Wir bieten 11 antikörper gegen AMHR2, aufgewachsen in Kaninchen, Ziege und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Entrez Zusammenfassung
This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.
Rolle bei Krankheiten
Persistent Muellerian duct syndrome 2: A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
