alpha 1 Catenin ist ein Gen, das durch das Symbol CTNNA1 kodiert wird. Andere Namen sind: Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13; CTNNA1. alpha 1 Catenin hat eine Masse von 100.07kDa, eine Aminosäurelänge von 906, und ist an Macular dystrophy, patterned, 2 beteiligt.
Wir bieten 9 antikörper gegen alpha 1 Catenin, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Huhn.
Gen- und Proteininformationen
UniProt Zusammenfassung
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Entrez Zusammenfassung
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy.
Gewebespezifität
Expressed ubiquitously in normal tissues.
Rolle bei Krankheiten
Macular dystrophy, patterned, 2: A form of retinal patterned dystrophy, a heterogeneous group of macular disorders caused by abnormal accumulation of lipofuscin in the retinal pigment epithelium. Lipofuscin distribution can show various shapes that define different types of macular dystrophy, including reticular (fishnet-like) dystrophy, macroreticular (spider-shaped) dystrophy and butterfly-shaped pigment dystrophy. MDPT2 is an autosomal dominant form characterized by bilateral accumulation of pigment in the macular area that resembles the wings of a butterfly.
Sequenzähnlichkeiten
Belongs to the vinculin/alpha-catenin family.
Posttranslationale Modifikation
Sumoylated.
Zellort
Cytoplasm > Cytoskeleton. Cell junction > Adherens junction. Cell membrane. Cell junction.
Found at cell-cell boundaries and probably at cell-matrix boundaries.
