alpha 1 Antichymotrypsin ist ein Gen, das durch das Symbol SERPINA3 kodiert wird. Andere Namen sind: Alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; Serpin A3; SERPINA3; AACT. alpha 1 Antichymotrypsin hat eine Masse von 47.65kDa und eine Aminosäurelänge von 423.
Wir bieten 32 antikörper gegen alpha 1 Antichymotrypsin, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Entrez Zusammenfassung
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Gewebespezifität
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Sequenzähnlichkeiten
Belongs to the serpin family.
Posttranslationale Modifikation
N- and O-glycosylated.
