ALDH1A1 ist ein Gen, das durch das Symbol ALDH1A1 kodiert wird. Andere Namen sind: Retinal dehydrogenase 1; RALDH 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; ALDC; ALDH1; PUMB1. ALDH1A1 hat eine Masse von 54.86kDa und eine Aminosäurelänge von 501.
Wir bieten 22 antikörper gegen ALDH1A1, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233).
Entrez Zusammenfassung
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.
Sequenzähnlichkeiten
Belongs to the aldehyde dehydrogenase family.
Posttranslationale Modifikation
The N-terminus is blocked most probably by acetylation.
Zellort
Cytoplasm > Cytosol.
