AKR1B10 ist ein Gen, das durch das Symbol AKR1B10 kodiert wird. Andere Namen sind: Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; Small intestine reductase; SI reductase; AKR1B11. AKR1B10 hat eine Masse von 36.02kDa und eine Aminosäurelänge von 316.
Wir bieten 6 antikörper gegen AKR1B10, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097).
Entrez Zusammenfassung
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
Gewebespezifität
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Sequenzähnlichkeiten
Belongs to the aldo/keto reductase family.
Zellort
Lysosome. Secreted.
Secreted through a lysosome-mediated non-classical pathway.
