AKAP12 ist ein Gen, das durch das Symbol AKAP12 kodiert wird. Andere Namen sind: A-kinase anchor protein 12; AKAP-12; A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen; AKAP250. AKAP12 hat eine Masse von 191.48kDa und eine Aminosäurelänge von 1782.
Wir bieten 3 antikörper gegen AKAP12, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Entrez Zusammenfassung
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Gewebespezifität
Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
Zellort
Cytoplasm > Cell cortex. Cytoplasm > Cytoskeleton. Membrane.
May be part of the cortical cytoskeleton.
