ADCY8 ist ein Gen, das durch das Symbol ADCY8 kodiert wird. Andere Namen sind: Adenylate cyclase type 8; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase. ADCY8 hat eine Masse von 140.12kDa und eine Aminosäurelänge von 1251.
Wir bieten 6 antikörper gegen ADCY8, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
Entrez Zusammenfassung
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase
Gewebespezifität
Detected in brain cortex (PubMed:1715695). Expressed in islet (PubMed:25403481).
Sequenzähnlichkeiten
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Posttranslationale Modifikation
Phosphorylated by PKA; mediates inhibition of adenylate cyclase activity at membrane raft; does not influence either CALM1 or PPP2CA interaction with ADCY8.
Zellort
Cell membrane. Basolateral cell membrane. Apical cell membrane. Cell junction > Synapse. Cell projection > Dendrite. Cell projection > Axon. Cell junction > Synapse > Presynaptic cell membrane. Cell junction > Synapse > Postsynaptic density. Membrane raft. Membrane > Coated pit. Cytoplasmic vesicle > Clathrin-coated vesicle membrane. Membrane > Caveola.
Localized to dendritic arbors (By similarity). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity).
