ADCY3 ist ein Gen, das durch das Symbol ADCY3 kodiert wird. Andere Namen sind: Adenylate cyclase type 3; ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; AC3; KIAA0511. ADCY3 hat eine Masse von 128.96kDa, eine Aminosäurelänge von 1144, und ist an Obesity beteiligt.
Wir bieten 7 antikörper gegen ADCY3, aufgewachsen in Kaninchen und Huhn, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Entrez Zusammenfassung
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663).
Rolle bei Krankheiten
Obesity: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Sequenzähnlichkeiten
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Posttranslationale Modifikation
Sumoylated. Sumoylation is required for targeting ot olfactory cilia.
Zellort
Cell membrane. Cytoplasm. Cell projection > Cilium. Golgi apparatus.
Also detected in the cytoplasm, close to lipid droplets.
