ADAMTS1 ist ein Gen, das durch das Symbol ADAMTS1 kodiert wird. Andere Namen sind: A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM-TS 1; METH-1; KIAA1346; METH1. ADAMTS1 hat eine Masse von 105.36kDa und eine Aminosäurelänge von 967.
Wir bieten 6 antikörper gegen ADAMTS1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Entrez Zusammenfassung
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
Posttranslationale Modifikation
The precursor is cleaved by a furin endopeptidase.
Zellort
Secreted > Extracellular space > Extracellular matrix.
