Acetylcholinesterase ist ein Gen, das durch das Symbol ACHE kodiert wird. Andere Namen sind: AChE; ACHE. Acetylcholinesterase hat eine Masse von 67.8kDa und eine Aminosäurelänge von 614.
Wir bieten 15 antikörper gegen Acetylcholinesterase, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC, IP and Dot mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Entrez Zusammenfassung
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.
Gewebespezifität
Isoform H is highly expressed in erythrocytes.
Sequenzähnlichkeiten
Belongs to the type-B carboxylesterase/lipase family.
Zellort
Cell junction > Synapse. Secreted. Cell membrane.
