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Anti-ACAT1 Antikörper

13 Products

ACAT1 ist ein Gen, das durch das Symbol ACAT1 kodiert wird. Andere Namen sind: Acetyl-CoA acetyltransferase, mitochondrial; Acetoacetyl-CoA thiolase; T2; ACAT; MAT. ACAT1 hat eine Masse von 45.2kDa, eine Aminosäurelänge von 427, und ist an 3-ketothiolase deficiency beteiligt.

Wir bieten 13 antikörper gegen ACAT1, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.

Gen- und Proteininformationen

UniProt Zusammenfassung
This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:17371050, PubMed:1715688, PubMed:7728148, PubMed:9744475).
Entrez Zusammenfassung
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
Rolle bei Krankheiten
3-ketothiolase deficiency: An autosomal recessive inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded. Urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, triglylglycine, butanone is increased. It seems likely that the severity of this disease correlates better with the environmental or acquired factors than with the ACAT1 genotype.
Sequenzähnlichkeiten
Belongs to the thiolase-like superfamily. Thiolase family.
Posttranslationale Modifikation
Succinylation at Lys-268, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity).
Zellort
Mitochondrion.
Datenbank-Links
Western Blot - Anti-ACAT1 Antibody (A89814) - Antibodies.com
(7)
Western Blot - Anti-ACAT1 Antibody (A84741) - Antibodies.com
(4)
Western Blot - Anti-ACAT1 Antibody (A5335) - Antibodies.com
(4)
Western Blot - Anti-ACAT1 Antibody (A84739) - Antibodies.com
(2)
Western Blot - Anti-ACAT1 Antibody (C14232) - Antibodies.com
(3)
Produkt anzeigen10µg Versuchsgrößen
Western Blot - Anti-ACAT1 Antibody (R12-2433) - Antibodies.com
Produkt anzeigen10µg Versuchsgrößen
Western Blot - Anti-ACAT1 Antibody (Biotin) (A84742) - Antibodies.com
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Produkt anzeigen5µg Versuchsgrößen
Anti-ACAT1 (K266) Antibody from Bioworld Technology (BS3796) - Antibodies.com
(5)
Western blot - ACAT1 Antibody from Signalway Antibody (32779) - Antibodies.com
(3)
ACAT1 Antibody from Signalway Antibody (35395) - Antibodies.com
(3)
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