5T4 ist ein Gen, das durch das Symbol TPBG kodiert wird. Häufige Alternativnamen sind: Trophoblast glycoprotein oncofetal antigen oncofetal trophoblast glycoprotein oncotrophoblast glycoprotein; M6P1; Wnt-activated inhibitory factor 1; WAIF1; TPBG. 5T4 hat eine Masse von 46.03kDa und eine Aminosäurelänge von 420.
Wir bieten 11 antikörper gegen 5T4, aufgewachsen in Kaninchen, Maus und Human, welche geeignet sind für WB, ELISA and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Entrez Zusammenfassung
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
Gewebespezifität
Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Posttranslationale Modifikation
Highly glycosylated.
