160 kD Neurofilament Medium ist ein Gen, das durch das Symbol NEFM kodiert wird. Häufige Alternativnamen sind: Neurofilament medium polypeptide; NF-M; 160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein; NEFM; NEF3; NFM. 160 kD Neurofilament Medium hat eine Masse von 102.47kDa und eine Aminosäurelänge von 916.
Wir bieten 3 antikörper gegen 160 kD Neurofilament Medium, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Entrez Zusammenfassung
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Sequenzähnlichkeiten
Belongs to the intermediate filament family.
Posttranslationale Modifikation
There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Zellort
Cytoplasm > Cytoskeleton. Cell projection > Axon.
