VEGFD ist ein Gen, das durch das Symbol VEGFD kodiert wird. Es ist auch bekannt als: Vascular endothelial growth factor D; VEGF-D; c-Fos-induced growth factor; FIGF. VEGFD hat eine Masse von 40.44kDa und eine Aminosäurelänge von 354.
Wir bieten 13 VEGFD ELISA-Kits zum qualitativen oder quantitativen Nachweis von VEGFD von Human, Maus, Ratte und Rind proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus.
Gewebespezifität
Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
Sequenzähnlichkeiten
Belongs to the PDGF/VEGF growth factor family.
Posttranslationale Modifikation
Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
