TGF alpha ist ein Gen, das durch das Symbol TGFA kodiert wird. Es ist auch bekannt als: Protransforming growth factor alpha; TGFA. TGF alpha hat eine Masse von 17.01kDa und eine Aminosäurelänge von 160.
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Gen- und Proteininformationen
UniProt Zusammenfassung
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Entrez Zusammenfassung
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.
Zellort
Secreted > Extracellular space.
