beta Defensin 1 ist ein Gen, das durch das Symbol DEFB1 kodiert wird. Andere Namen sind: Beta-defensin 1; BD-1; Defensin, beta 1; DEFB1; BD1; HBD1. beta Defensin 1 hat eine Masse von 7.42kDa und eine Aminosäurelänge von 68.
Wir bieten 16 beta Defensin 1 ELISA-Kits zum qualitativen oder quantitativen Nachweis von beta Defensin 1 von Human, Maus, Ratte, Rind, Schwein und Goat proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).
Entrez Zusammenfassung
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.
Gewebespezifität
Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
Sequenzähnlichkeiten
Belongs to the beta-defensin family.
Zellort
Secreted. Membrane.
Associates with tumor cell membrane-derived microvesicles (PubMed:23938203).
