Angiotensinogen ist ein Gen, das durch das Symbol AGT kodiert wird. Andere Namen sind: Serpin A8; AGT; SERPINA8. Angiotensinogen hat eine Masse von 53.15kDa, eine Aminosäurelänge von 485, und ist an folgenden Krankheiten beteiligt: Essential hypertension; Renal tubular dysgenesis.
Wir bieten 11 Angiotensinogen ELISA-Kits zum qualitativen oder quantitativen Nachweis von Angiotensinogen von Human, Maus, Ratte, Schwein und Affe proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Entrez Zusammenfassung
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Gewebespezifität
Expressed by the liver and secreted in plasma.
Rolle bei Krankheiten
Essential hypertension: A condition in which blood pressure is consistently higher than normal with no identifiable cause.
Renal tubular dysgenesis: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Sequenzähnlichkeiten
Belongs to the serpin family.
Posttranslationale Modifikation
Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
